Fig. 5: EvoWeaver’s ensemble predictions can generate high-fidelity biological hypotheses.
From: EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals
a The protein product of B3GNT5 promotes the expression of ST6GAL165, although this connection is missing in KEGG and STRING. b EvoWeaver’s component and ensemble predictions indicate that B3GNT5 and ST6GAL1 are functionally associated, which is supported by experiments in human cell culture65. c Phylogenetic Profiling demonstrates a pattern of association between B3GNT5 and ST6GAL1, although it is supported by relatively few gain/loss events on the reference tree. d Organisms with both B3GNT5 and ST6GAL1 on the same chromosome display correlations in gene orientation and modest signal of colocalization. e Shared patristic distances from both gene trees are correlated, especially after compression with random projection, suggesting a high degree of coevolution between B3GNT5 and ST6GAL1. f Gene sequence natural vectors for both B3GNT5 and ST6GAL1 are moderately correlated, implying similar residue compositions and providing further signal of coevolution. Source data are provided as a Source Data file. Created in BioRender. Lakshman, A. (2025) https://BioRender.com/u57r428.
