Fig. 2: Nodose ganglia population responses reveal subsets of cytokine‐specific neurons while others respond to multiple cytokines.
From: Neural representation of cytokines by vagal sensory neurons
a Representative field of view showing neurons that respond to specific cytokines. b Representative traces from individual sensory neurons responding to specific cytokines. c Heatmap demonstrating selective cytokine‐specific responses in normalized neural activity index. White dotted lines indicate the time of cytokine application on the vagus nerve. d Pie chart depicting the proportion of total responsive neurons to specific cytokines, multiple cytokines or nonspecific activity. e Representative confocal microscopy images showing antibody labeling of IL‐1R1 (red) and TNFR1 (green) cytokine receptors on nodose ganglia cell bodies. Scale bar, 50 µm; Zoomed inset scale bar, 25 µm. IHC was repeated independently in 5 mice, quantified over 2 sections each. f Quantification of nodose ganglion cell bodies labeled for IL‐1R1 and TNFR1.
