Fig. 5: Specific gene pathways related to neuronal and inflammatory signaling are altered in DSS-colitis vagal ganglia.
From: Neural representation of cytokines by vagal sensory neurons
a Schematic showing the process for transcriptomic analyses of vagal ganglia from DSS-colitis mice. Created in BioRender. Chang, E. (2025) https://BioRender.com/poklo2e (b) Volcano plot showing individual transcriptomic changes in vagal ganglia from mice with DSS‐colitis. Upregulated neuronal signaling associated genes (Scn10a, Syt7, Cacna1h, Cacna2d2, Grin3b, Grik4, Kcnk18, Kcnj12, Tpcn1, Dbh), downregulated inflammation associated genes (S100a8, Ramp1, Ramp2, Tnfrsf12a, Tank, Tlr3, Il12a, Cxcl2, Ccl3, Ccl11). P-adjusted value was calculated using Benjamini-Hochberg correction, significance threshold was FDR < 0.05. c Weighted dot plot of a selection of significantly enriched biological pathways reveals upregulated neuronal pathways at peak colitis. d Weighted dot plot shows selected sets of downregulated genes associated with inflammatory signaling.
