Fig. 2: The frequencies and expansion ability of circulating MAIT cells from LF patients are gradually recovered after liver transplant.

A, B Representative plots (A) and summarized frequencies (B) of circulating MAIT(cMAIT) from liver transplanted (LT) recipients in indicated time points (n = 28/group). Statistical significance was assessed by a two-sided paired Student’s t test. C The dynamic changes of the frequencies of cMAIT cells in LT recipients of 1-year follow-up are exhibited by a line chart (left panel, n = 10). Summarized graphs (right panel) of the frequencies of cMAIT cells from LT 1 year post (n = 10) and HD (n = 10). Statistical significance was assessed by a two-sided paired Student’s t test. D Summarized frequencies of circulating CD161^-TCRVα7.2⁺ cells from liver transplanted recipients in indicated time points (left panel, n = 28/group) and the dynamic changes of the frequencies of CD161^-TCRVα7.2⁺ cells in LT recipients of 1 year follow-up are exhibited by a line chart (right panel, n = 10). Statistical significance was assessed by a two-sided paired Student’s t test. E Flow chart of MAIT cell expansion from PBMCs stimulated upon antigen-presenting cells (aAPCs) loaded with 5-OP-RU/MR1 in the presence of IL-2. F Representative frequencies (left panel) and expansion fold (right panel) of circulating MAIT cell expansion from PBMCs in HD (n = 24), LF (n = 16), and LT (n = 20) groups. Statistical significance was assessed by the Kruskal-Wallis test followed by Dunn’s test. Data are presented as mean ± SEM. n-values represent biological replicates. Source data are provided as a Source Data file.