Fig. 4: Enhanced trafficking between circulating and hepatic MAIT cells in the liver failure patients and liver transplant recipients.

A Principle component analysis (PCA) clustering based on transcriptome of cMAIT-HD (n = 6), cMAIT-LF (n = 3), hMAIT-HBVN (n = 2), hMAIT-Comp (n = 4), and hMAIT-LF (n = 3). B Uniform manifold approximation and projection (UMAP) clustering plots (upper panel) for distribution of the cMAIT and hMAIT from healthy control (HC, n = 6), immune active (IA, n = 5), and immune tolerant (IT, n = 6) groups sourced from dataset GSE182159. C The relative transcription levels (log₂FC) of indicated genes in cMAIT-LF (n = 3) versus cMAIT-HD (n = 6), and hMAIT-LF (n = 3) versus hMAIT-HBVN(n = 2) & Comp(n = 4). D CCR6 and CXCR6 levels of cMAIT-HD (CCR6 (n = 62), CXCR6 (n = 14)), cMAIT-Comp (CCR6(n = 24), CXCR6 (n = 3)), and cMAIT-LF (CCR6(n = 24), CXCR6 (n = 7)). Data were collected from at least three independent experiments. Statistical significance was assessed by a one-way ANOVA test followed by Fisher’s LSD test. E The level of CXCR6 (n = 5) and CCR6 (n = 14) of cMAIT pretransplant and around 1-week posttransplant. Data were collected from at least five independent experiments. Data are presented as mean ± SEM. n-values represent biological replicates. Statistical significance was assessed by the two-sided paired Student’s t test. Source data are provided as a Source Data file.