Fig. 5: TCR usages and overlapping TCR clonotypes of circulating and hepatic MAIT cells. | Nature Communications

Fig. 5: TCR usages and overlapping TCR clonotypes of circulating and hepatic MAIT cells.

From: Liver transplant-facilitated CD161+Vα7.2+ MAIT cell recovery demonstrates clinical benefits in hepatic failure patients

Fig. 5

TCR usages and clonotypes of MAIT cells were analyzed among immune active (IA, n = 5), immune tolerance (IT, n = 6), and healthy control (HC, n = 6) groups sourced from dataset GSE182159. A Chord diagrams depict TRAJ and TRBV usages of MAIT cells defined by TRAV1-2+SLC4A10+ in the indicated groups. B The bar graph, featuring different colors, depicts the ratios of clones with varying frequencies of identical CDR3α or CDR3β sequences. C The bar graphs depict ratios of clones with varying frequencies of identical paired CDR3α and CDR3β sequences in both blood and liver of the indicated groups. D TCR diversity assessed by the Shannon equitability index in IA (n = 5), HC (n = 6), and IT (n = 6) groups. Data are presented as mean ± SEM. n-values represent biological replicates. Statistical significance was assessed by a one-way ANOVA test followed by Fisher’s LSD test. Source data are provided as a Source Data file. E The chord diagrams show the frequencies of the liver-blood sharing TCR clonotypes among MAIT cells with clonal frequency over 5 in the indicated groups with patient ID, Clone name, and clone frequency (ID:Clone:Freq) of each clonotypes as axis labels.

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