Fig. 8: The restored circulating MAIT cells indicate favorable clinical outcome.

A Spearman correlation between the frequencies of circulating MAIT cells from the recipients posttransplant and the serum levels of indicated clinical parameters (Alanine aminotransferase (ALT(n = 28)), Aspartate aminotransferase (AST(n = 28)), Total bilirubin (TBIL(n = 28)), Direct bilirubin (DBIL(n = 28)), Indirect bilirubin (IBIL(n = 28)), Total protein (TP, (n = 28))). Data were collected from twenty-eight independent experiments and are presented as mean ± SEM. B The proportion of the recipients with (n = 12) or without (n = 16) complications (upper panel) and the types of complications and occurrence days posttransplant are depicted in the right panel by scatter plot (lower panel). Different colored symbols indicate distinct individuals in those with complications. C Dynamic changes of frequencies (%, 0 d(n = 16), 3 d(n = 4), 7 d(n = 16), 14 d(n = 8), 30 d(n = 16)) and number (#, n = 15/time point) of cMAIT-LT in patients without complications. Statistical significances are statistically analyzed by a two-tailed paired Student’s t test. D Dynamic changes of frequencies (%, 0 d (n = 12), 3 d (n = 5), 7 d (n = 12), 14 d (n = 12), 30 d (n = 12)) and number (#, n = 12/time point) of cMAIT-LT in patients with complications. Different colored symbols indicate distinct individuals in those with complications. Statistical significances are statistically analyzed by a two-tailed paired Student’s t test between each pair of two groups. E The change rate of MAIT cells and CD8⁺non-MAIT cells frequencies and numbers at 30-day posttransplant compared with day 0 was depicted by scatter graphs with complications (n = 12)/without complications (n = 16). Data were collected from twenty-eight independent experiments and are presented as mean ± SEM. n-values represent biological replicates. Statistical significance was statistically analyzed by the Mann-Whitney test. Source data are provided as a Source Data file.