Fig. 2: Structural details of interdomain interfaces stabilizing the CELSR1 ECR compact bundle.
From: Structural basis for regulation of CELSR1 by a compact module in its extracellular region
a Cartoon representation of CELSR1 ECR structure with key interfaces enclosed in black rectangles. CADH cadherin repeat (yellow), FBox Flamingo Box domain (pink), EGF epidermal growth factor repeat (teal), LamG laminin G repeat (lime green), HormR hormone receptor domain (green), GAIN GPCR autoproteolysis-inducing domain (purple), 7TM seven transmembrane region. b Cartoon model showing the interface between CADH9 and GAIN domains. Important residues are shown as sticks. c Cartoon model showing the interface between EGF2 and EGF7 domains with important residues shown as sticks. d Cartoon model showing the EGF6/LamG1 interface with important residues shown as sticks.
