Fig. 1: MPXV-specific memory T cell response in mpox convalescent individuals and healthy controls (HC). | Nature Communications

Fig. 1: MPXV-specific memory T cell response in mpox convalescent individuals and healthy controls (HC).

From: T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

Fig. 1

A Study design (Created in BioRender. Antoun, E. (2025) https://BioRender.com/a25q267). B Representative IFN-γ ELISpot response after stimulation with VACV. C Summary of VACV-induced memory T cell response in mpox convalescent (N = 13) and healthy control (HC, N = 10) participants. Data are presented as median ± IQR. D Representative flow cytometry plots measuring expression of activation-induced markers on VACV-reactive CD8+ and CD4+ T cells from mpox convalescent participants. E Overall percentage of VACV-reactive CD8+ and CD4+ T cells in total T cells. Data are presented as median ± IQR (N = 11). F Individual and overall relative proportion of VACV-reactive CD8+ (red) and CD4+ (blue) T cells, N = 11. The Mann–Whitney U-test was used for the analysis and two-tailed P values were calculated. ns not significant; IQR interquartile range. Source data are provided as a Source Data file.

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