Fig. 2: Memory T cell responses in MPXV-convalescent individuals against epitope mega pools of early and intermediate/late antigens. | Nature Communications

Fig. 2: Memory T cell responses in MPXV-convalescent individuals against epitope mega pools of early and intermediate/late antigens.

From: T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

Fig. 2

A Schematic graph of MPXV epitope mega pool design (see the “Methods” section for more details, Created in BioRender. Antoun, E. (2025) https://BioRender.com/a25q267). B T cell responses against MPXV CD4+/CD8+ early proteins (red) or intermediate/late proteins (blue), N = 12. C Overall T cell responses against overlapping peptide pools covering the full length of five selected MPXV antigens, N = 12. Boxplots represent the 25th and 75th percentiles with the median marked with whiskers at ±1.5*IQR. D, E Comparison of overall T cell response against VACV and that against MPXV mega pools (N = 12). A paired Wilcoxon signed-rank test for B and D was used and two-tailed P values were calculated. ns not significant, SFU spot forming units, MPXV Mpox virus, VACV vaccinia virus. Source data are provided as a Source Data file.

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