Fig. 6: scRNAseq transcriptomic comparison between MPXV-specific and SARS-CoV-2-specific CD8+ T cells. | Nature Communications

Fig. 6: scRNAseq transcriptomic comparison between MPXV-specific and SARS-CoV-2-specific CD8+ T cells.

From: T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

Fig. 6

A Dot plot of the gene expression of cells from convalescent and vaccinated individuals for cytokines, cytotoxicity molecules, integrins and activation markers. B Comparison of module scores for cytokines, integrins, cytotoxicity genes, activation-related genes and chemokines between MPXV-specific (401 and 160 cells from convalescence and vaccination, respectively) and SARS-CoV-2-specific CD8+ T cells (912 cells). C Violin plots depicting the expression of select genes between MPXV-specific and SARS-CoV-2-specific CD8+ T cells. D Comparison of cytotoxicity molecules and integrins expressed on ILD-tetramer+CD8+ T cells between convalescent (N = 5) and vaccinated (N = 5) individuals by flow cytometry. The Wilcoxon signed-rank test was used in (B) and (C). In D, the Kolmogorov–Simonov test was used to test for normality and an unpaired t-test was used for CD29 and the Mann–Whitney U-test was used for the rest. Boxplots in B and D represent the 25th and 75th percentiles with the median marked with whiskers at ±1.5*IQR. Two-tailed p values were calculated. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05. Source data are provided as a Source Data file.

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