Fig. 10: Mcl-1 inhibition accelerated functional recovery from ischemic injury with less post-ischemia fibrosis. | Nature Communications

Fig. 10: Mcl-1 inhibition accelerated functional recovery from ischemic injury with less post-ischemia fibrosis.

From: Myeloid EGFR deficiency accelerates recovery from AKI via macrophage efferocytosis and neutrophil apoptosis

Fig. 10

A Male C57BL/6 (8 weeks old) mice underwent ischemic injury (renal pedicle clamping, 35 min, both kidneys, Bi-IRI)), and the Mcl-1 inhibitor (S63845) was given 6 h later and daily for the next 5 days via intravenous injection at a dose of 5 mg/kg. The mice were sacrificed 3 weeks later. Mcl-1 inhibition accelerated functional recovery, indicated by: B rapid BUN decline (n = 9 and 10), C preserved GFR (n = 8) and attenuation of the development of kidney fibrosis, indicated by: D lower mRNA levels (n = 6 and 9) and E protein levels (n = 7) of profibrotic and fibrotic components as well as F quantitative Picrosirius red staining (n = 6) (F). Scale bar=100 μm. Data are means ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, analyzed using 2 tailed Student’s t test for all.

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