Fig. 4: Clinical associations with overall survival and mutation status. | Nature Communications

Fig. 4: Clinical associations with overall survival and mutation status.

From: Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinoma

Fig. 4

A HPV-independent SNSCC with TP53 mutations demonstrate an association with significantly decreased overall survival (P = 0.0093, Log-rank test: χ² = 6.757, df = 1; TP53 normal (n = 13), TP53 mutant (n = 6)). B HPV-associated SNSCC with KMT2D mutations demonstrate an association with significantly decreased overall survival (P = 0.0377; Log-rank test: χ² = 4.316, df = 1; KMT2D normal (n = 26), KMT2D mutant (n = 11)). C HPV-associated SNSCC with FGFR3 mutations demonstrate an association with decreased overall survival (P = 0.0516; Log-rank test: χ² = 3.789, df=1; FGFR3 normal (n = 31), FGFR3 mutant (n = 6)). D HPV-associated CESC from TCGA with KMT2D mutations demonstrate an association with decreased overall survival (P = 0.0105; Log-rank test: χ² = 6.54, df = 1; KMT2D normal (n = 123), KMT2D mutant (n = 17)). E HPV-associated HNSCC from TCGA with KMT2D mutations and overall survival (P = 0.4117; Log-rank test: χ² = 0.6738, df = 1; KMT2D normal (n = 67), KMT2D mutant (n = 11)). Survival curves were compared using a two-tailed Log-rank (Mantel–Cox) test. Source data are provided as a Source data file.

Back to article page