Table 1 The top nine affected drugs with the description

From: Predicting rare drug-drug interaction events with dual-granular structure-adaptive and pair variational representation

Rank

Drug name

Description

Antiplatelet

1

Clopidogrel

A prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke68.

2

Idarubicin

An anthracycline antineoplastic agent, showing activity against leukemias69.

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3

Vinorelbine

An anti-mitotic chemotherapy drug, used in the treatment of malignancies. Its side effects relate to antiplatelet70.

4

Ticlopidine

A platelet aggregation inhibitor used in the prevention of conditions associated with thrombi71.

5

Tamoxifen

A non-steroidal antiestrogen, with direct inhibition of platelet activation for cardiovascular effects72.

6

Danazol

A synthetic steroid, having a certain effect on immune thrombocytopenic purpura (ITP)73.

7

Mipomersen

An oligonucleotide drug for hypercholesterolemia, associating with clinically insignificant platelet declines74.

8

Chloroquine

An aminoquinolone derivative for systemic lupus erythematosus by regulating antiplatelet effect, and lipid75.

9

Quinine

An alkaloid derived from the bark of the cinchona tree related to antiplatelet76.