Fig. 1: DNA induces assembly of PR-A and PR-B.
From: Structural proteomics defines a sequential priming mechanism for the progesterone receptor
a, b SEC-MALS chromatograms of agonist (R5020)- bound PR-A (a) and PR-B (b) with and without DNA. The molar mass of DNA and PR-A alone matches the monomeric molar mass (black line/dots across the peaks). DNA induces assembly of both PR-A and PR-B into a complex with 2:1 (protein:DNA) stoichiometry. The presence of DNA in the complexes was confirmed by deconvolution of the protein and DNA fractions in the peak (red and blue lines, respectively). Source data are provided as a Source Data file.
