Fig. 1: The proposed mechanisms for Tsix regulation of Xist. | Nature Communications

Fig. 1: The proposed mechanisms for Tsix regulation of Xist.

From: Transcriptional stochasticity reveals multiple mechanisms of long non-coding RNA regulation at the Xist–Tsix locus

Fig. 1

Transcript-based mechanisms (a-c) are on the top row, and mechanisms based on the act of transcription (d-e) are on the bottom row. a RNA interference (RNAi) machinery could cause degradation in response to double-stranded RNA due to Xist and Tsix binding in the same cell34. b Binding of Tsix to Xist could prevent proteins important for XCI from binding to Xist16. c Tsix could act as a scaffold to recruit proteins that would inhibit Xist35. d Polymerases could collide and inhibit transcription through transcriptional interference (TI)36. e Proteins can bind to the polymerase tails and cause chromatin changes during transcription14,37,38,39,40.

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