Fig. 6: Anticoagulant evaluation of fucoidan library.
From: Comprehensive synthesis and anticoagulant evaluation of a diverse fucoidan library
a Effects of the fucoidans on the prolongation of APTT, TT, and PT. Fucoidans were all at 128 μg/mL, Enox was at 4, 16, and 100 μg/mL for TT, APTT, and PT, respectively. Experiments were conducted in triplicate, and mean values were presented. b EC2.0× values of active fucoidans, assessing their inhibition of the intrinsic coagulation pathway by APTT. c Effects of the most potent compounds (29, 30, 37, and 58) on intrinsic coagulation factor Xase (iFXase) activity. Experiments were conducted in duplicate, and data were presented as mean. d IC50 values of 29, 30, 37, and 58 against iFXase and their effects on FXa and FIIa in the presence of antithrombin. APTT, activated partial thromboplastin time; PT, prothrombin time; TT, thrombin time.
