Fig. 1: Chromatin landscape of myometrium and UL genetic subclasses.

a Finland myoma study consists of 2061 ULs collected from 656 patients. The middle panel shows data created and analyzed in this study, and the right-hand panel depicts previously created data integrated to new data layers in this study. The schematic shows all data types utilized in this study, and shows how chromatin segmentations are created from ChIP-seq data with an example myometrium sample. Created in BioRender. Räisänen, M. (2025) https://BioRender.com/99cfkej. b 15-state chromatin annotation of myometrium correlates with the previous 5-state model and provides more specific annotations for the regulatory genome. A darker blue color corresponds to a greater fold enrichment for a column-specific coloring scale. ReprPC: Repressed by Polycomb; Quies: quiescent chromatin; TssBiv: Bivalent/poised TSS; TssA: Active TSS; OtherA: other active chromatin. c UL subclasses cluster separately based on chromatin annotations. d Genome-wide contribution of each of the 15-state annotations in myometrium and three UL subclasses. TssA Active TSS, TssAFlnk Flanking active TSS, TxFlnk Transcr. at gene 5’ and 3’, Tx Strong transcription, TxWk Weak transcription, EnhG Genic enhancers, Enh Enhancers, ZNF/Rpts ZNF genes + repeats, Het Heterochromatin, TssBiv Bivalent/poised TSS, BivFlnk Flanking bivalent TSS/Enh, EnhBiv Bivalent enhancer, ReprPC Repressed Polycomb, ReprPCWk Weak repressed Polycomb, Quies Quiescent/low. Source data are provided as a Source Data file.