Fig. 2: 15-state chromatin annotation of myometrium and UL subclasses provides insight into biological changes seen in other data types. | Nature Communications

Fig. 2: 15-state chromatin annotation of myometrium and UL subclasses provides insight into biological changes seen in other data types.

From: Chromatin state origins of uterine leiomyoma

Fig. 2

a More accessible regions are enriched at enhancers (Enh) in all UL subclasses. All tested regions in differential analyses were used as background in enrichment analyses. b Hypermethylated loci in MED12 and HMGA2 are enriched at bivalent regions (TssBiv and BivFlnk), and at enhancers in FH ULs. c Hypomethylated regions in MED12 and HMGA2 ULs are enriched at active annotations (TssAFlnk, TxFlnk, Enh and EnhG). Statistics are calculated with Fisher’s exact test implemented in the LOLA package. TssA Active TSS, TssAFlnk Flanking active TSS, TxFlnk Transcr. at gene 5’ and 3’, Tx Strong transcription, TxWk Weak transcription, EnhG Genic enhancers, Enh Enhancers, ZNF/Rpts ZNF genes + repeats, Het Heterochromatin, TssBiv Bivalent/poised TSS, BivFlnk Flanking bivalent TSS/Enh, EnhBiv Bivalent enhancer, ReprPC Repressed Polycomb, ReprPCWk Weak repressed Polycomb, Quies Quiescent/low. Source data are provided as a Source Data file.

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