Fig. 5: Altered serotonin signalling variously impacts transient, translaminar GABAergic circuits in postnatal S1BF. | Nature Communications

Fig. 5: Altered serotonin signalling variously impacts transient, translaminar GABAergic circuits in postnatal S1BF.

From: Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding

Fig. 5

a Diagram showing the breeding paradigm used to generate wildtype (wt) or SERT-het (het) pups from wildtype dams. b Average LSPS maps for total GABAergic input onto L4 SSNs recorded in pups generated from the breeding paradigm shown in (a) mice during the P4-6 time window (wt pups, n = 7 cells; het pups, n = 5 cells). c Profile of GABAergic input across the depth of cortex from the maps shown in (b). L5b input was present in both WT and het pups born from WT dams. d Total L5b GABAergic input onto L4 SSNs recorded in animals bred from SERT-Het male and WT female pairs across postnatal development, broken down according to the genotype of the pup (wt/het)(mean ± SEM); wt: P4-6, n = 7 cells; P7-9, n = 4; P10-14, n = 11; het: P4-6, n = 4; P7-9, n = 7; P10-14, n = 11. e GABAergic input maps for L2/3 PYRs during the P7-9 time window (wt pups, n = 7 cells; het pups, n = 12 cells). f Profile of GABAergic input across the depth of cortex from the maps shown in (e). g timeline of L5b GABAergic innervation of L2/3 PYRs (mean ± SEM); (Two tailed t-test: P4-6, p = 0.048; P7-9, p = 0.009, P10-14, p = 0.344); wt: P4-6, n = 8 cells; P7-9, n = 7; P10-14, n = 14; het: P4-6, n = 9; P7-9, n = 12; P10-14, n = 13.

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