Fig. 1: Overall structure of apo-hXPR1.
From: The identification of XPR1 as a voltage- and phosphate-activated phosphate-permeable ion channel
a The composite Cryo-EM density map (left) and cartoon representations of the atomic model (middle and right) of apo-hXPR1 dimer viewed in the membrane plane from two orthogonal directions. Two protomers are colored magenta and lavender. The densities of the cytosolic domain and TMD are displayed at a contour level of 8.17σ and 5.04σ, respectively. The gray box in the background indicates the membrane bilayer. b Cartoon representations of an hXPR1 monomer viewed from the side and from top-down. The SPX domain is colored in yellow, the EXS domain in light blue, and the rest of the protein in gray. c Topology of a monomeric hXPR1.
