Fig. 2: Opposite changes are seen in excitatory synaptic transmissions of Ptprd-meB+/– dentate granule cells versus interneurons. | Nature Communications

Fig. 2: Opposite changes are seen in excitatory synaptic transmissions of Ptprd-meB+/– dentate granule cells versus interneurons.

From: Alternatively spliced mini-exon B in PTPδ regulates excitatory synapses through cell-type-specific trans-synaptic PTPδ-IL1RAP interaction

Fig. 2

a Experimental scheme for measuring mE/IPSCs and sEPSCs in dentate gyrus granule cells (DG-GCs) from the ventral hippocampus (vHPC) of Ptprd-meB+/– mice (P56–70; male). M/LEC, medial/lateral entorhinal cortex. b mEPSC frequencies and amplitudes in WT and Ptprd-meB+/– DG-GCs (P56–70; male). (n = 15 neurons from 5 mice [WT],16, 5 [Ptprd-meB+/–/HT], two-tailed Welch’s t-test [frequency], two-tailed Mann–Whitney test [amplitude], Frequency P = 0.0075). c sEPSC frequencies and amplitudes in WT and Ptprd-meB+/– DG-GCs (P56–70; male). (n = 23, 6 [WT], 18, 7 [HT], two-tailed Mann-Whitney test). d mIPSC frequencies and amplitudes in WT and Ptprd-meB+/– DG-GCs (P56–70; male). (n = 18, 5 [WT], 17, 4 [HT], two-tailed Mann-Whitney test [frequency], two-tailed Student’s t-test [amplitude]). e mEPSC frequencies and amplitudes in WT and Ptprd-meA+/– DG-GCs (P56–70; male). (n = 21, 4 [meA+/+], 19, 3 [meA+/–], two-tailed Mann-Whitney test [frequency], two-tailed Student’s t-test [amplitude]). f Experimental scheme for measuring mEPSCs and sEPSCs in dentate gyrus interneurons (DG-INs) from vHPC of Ptprd-meB+/– mice (P56–70; male). g mEPSC frequencies and amplitudes in DG-INs from WT and Ptprd-meB+/– mice (P56–70; male). (n = 16, 5 [WT], 17, 6 [HT], two-tailed Mann–Whitney test, Frequency P = 0.0285). h sEPSC frequencies and amplitudes in DG-INs from WT and Ptprd-meB+/– mice (P56–70; male). (n = 16, 6 [WT], 18, 7 [HT], two-tailed Mann-Whitney test [frequency], two-tailed Student’s t-test [amplitude]). Data values represent means ± SEM. Significance is indicated as *(<0.05), **(<0.01), or ns (not significant). Source data are provided as a Source Data file.

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