Table 1 Glycosphingolipid species detected by µL-flow 4D-RP-LC-TIMS-PASEF analysis in human serum

From: Extended coverage of human serum glycosphingolipidome by 4D-RP-LC TIMS-PASEF unravels association with Parkinson’s disease

Class	Subclass	Sphingoid base	Fatty acyl chain length	Number of double bonds in the fatty acyl chain	Degree of hydroxylation in fatty acyl chain	Number of species	Total
Gangliosides	GM3	18:0;O2	C14–C22	0	0	5	66
		18:1;O2	C10–C26	0–3	0	37
		18:0;O3	C16–C22	0	0	2
		18:1;O3	C10–C24	0–2	0	22
	GM2	18:1;O2	C16–C18	0–1	0	3	3
	GM1	18:1;O2	C16–C18	0	0	2	2
	GD3	18:0;O2	C16	0	0	1	17
		18:1;O2	C14–C24	0–2	0	15
		18:1;O3	C16	0	0	1
	GD2	18:1;O2	C16–C24	0–1	0	4	4
	GD1	18:0;O2	C16	0	0	1	18
		18:1;O2	C14–C24	0–2	0	15
		18:1;O3	C16–C18	0	0	2
	GT1b	18:0;O2	C16	0	0	1	13
		18:1;O2	C14–C24	0–2	0	12
	GQ1b	18:1;O2	C16–C18	0	0	2	2
	O-acetyl GD1	18:1;O2	C16–C18	0–1	0	3	3
	Fuc-GD1	18:1;O2	C20	0	0	1	1
Sialylated neolacto-series	Neu5Ac-nLc4Cer	18:1;O2	C14–C24	0–2	0	10	10
	Neu5Ac-nLc6Cer	18:1;O2	C16–C24	0–2	0	6	6
	Neu5Ac-nLc8Cer	18:1;O2	C16–C24	0–1	0	3	3
	Neu5Ac-nLc10Cer	18:1;O2	C16	0	0	1	1
	Neu5Ac-Fuc-nLc6Cer	18:1;O2	C16–C18	0–1	0	3	3
	Neu5Ac-Fuc-nLc8Cer	18:1;O2	C16–C24	0–1	0	3	3
	Neu5Ac-Fuc-nLc10Cer	18:1;O2	C16	0	0	1	1
	Neu5Ac-Fuc-nLc12Cer	18:1;O2	C16	0	0	1	1
	Neu5Ac-Fuc2-nLc10Cer	18:1;O2	C16	0	0	1	1
	Neu5Ac-Fuc2-nLc12Cer	18:1;O2	C16	0	0	1	1
Neutral glycosphingolipids	HexCer	16:1;O2	C18–C24	0–1	0–1	8	45
		17:1;O2	C24	0	0	1
		18:1;O2	C16–C24	0–2	0–1	19
		18:2;O2	C16–C24	0–1	0–1	13
		18:0;O3	C16–C24	0–1	0–1	3
		18:0;O4	C24	1	0	1
	Hex2Cer	16:1;O2	C14–C24	0–2	0–1	11	53
		16:2;O2	C16	0	0	1
		17:1;O2	C16–C24	0–1	0	4
		17:2;O2	C16	0	0	1
		18:0;O2	C16	0	0	1
		18:1;O2	C12–C24	0–2	0–1	19
		18:2;O2	C12–C24	0–2	0–1	14
		18:1;O3	C16	0	0	1
		Unidentified sphingoid base	Unidentified fatty acyl chain	–	–	1
	Hex3Cer	16:1;O2	C12–C22	0	0–1	6	34
		17:1;O2	C16–C18	0	0	2
		18:0;O2	C16	0	0	1
		18:1;O2	C10–C24	0–2	0–1	13
		18:2;O2	C12–C24	0–1	0–1	11
		Unidentified sphingoid base	Unidentified fatty acyl chain	–	–	1
	HexNAcHex3Cer	16:1;O2	C16	0	0	1	11
		17:1;O2	C16	0	0	1
		18:1;O2	C14–C24	0–1	0	5
		18:2;O2	C16–C22	0	0	2
		Unidentified sphingoid base	Unidentified fatty acyl chain	–	–	2
	HexNAcHex4Cer	18:1;O2	C16	0	0	1	1
	Fuc-HexNAcHex3Cer	18:1;O2	C16	0	0	1	1
Sulfatides	SHexCer	16:1;O2	C16–C24	0–1	0–1	7	58
		17:1;O2	C16	0	0–1	2
		18:0;O2	C16	0	0–1	2
		18:1;O2	C14–C24	0–1	0–1	17
		18:2;O2	C16–C24	0–1	0–1	14
		16:0;O3	C18–C24	0–1	0–1	3
		18:0;O3	C16–C24	0–1	0–1	5
		18:1;O3	C16	0	1	1
		18:0;O4	C24	2	0	1
		Unidentified sphingoid base	Unidentified fatty acyl chain	–	–	6
	SHex2Cer	16:1;O2	C18	0	1	1	14
		18:1;O2	C16–C24	0–1	0–1	5
		18:2;O2	C16–C24	0–1	0	4
		Unidentified sphingoid base	Unidentified fatty acyl chain	–	–	4

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Table 1 Glycosphingolipid species detected by µL-flow 4D-RP-LC-TIMS-PASEF analysis in human serum

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