Fig. 4: PHOTON reveals the functional role of m⁶A in mRNA recruitment into SGs.

A Cumulative distribution plot of transcript abundance in the sodium arsenite-induced SGs of normal HeLa cells, binned based on the transcript length. Numbers in the parentheses indicate the number of transcripts in each bin. Source data are provided as a Source Data file. B m⁶A modifications may facilitate the partitioning of mRNAs into SGs through m⁶A-binding proteins. The schematic was created using BioRender. C Dose-dependent depletion of mRNA m⁶A modifications using METTL3 inhibitor STM2457. n = 3 independent replicates. The box represents the range between the first and third quartiles of the data. The line within the box indicates the mean. The whiskers extend to the furthest data points. Source data are provided as a Source Data file. D Cumulative distribution plot of transcript abundance in sodium arsenite-induced SGs of STM2457 (100 μM)-treated HeLa cells, binned based on the transcript length. Numbers in the parentheses indicate the number of transcripts in each bin. Source data are provided as a Source Data file.