Fig. 7: ISG and cytotoxicity scores are increased in the kidney in ANCA-GN and lupus nephritis. | Nature Communications

Fig. 7: ISG and cytotoxicity scores are increased in the kidney in ANCA-GN and lupus nephritis.

From: Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice

Fig. 7

a Transcriptome data of kidney biopsies from healthy controls, lupus nephritis, and ANCA-GN were analyzed. b Heatmap showing the expression of IFN-I and cytotoxicity-associated genes in the kidney. Graphs show the quantification of ISG and cytotoxicity scores based on the genes in the heatmap (Control, n = 21; Lupus nephritis, n = 33; ANCA-GN, n = 20). c Scatter plots showing the correlation between ISG score and cytotoxicity score. Each dot represents a patient. Scatter plots showing the correlation of SPP1 with ISG score or cytotoxicity score in ANCA-GN (d) and in lupus nephritis (e). b P values were calculated by one-way ANOVA with Tukey’s multiple comparison test. c–e P values were calculated using Pearson correlation with a two-sided test. Source data are provided as a Source Data file.

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