Fig. 6: NPCs increased in Q84Pfs-Het cortex. | Nature Communications

Fig. 6: NPCs increased in Q84Pfs-Het cortex.

From: The patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome

Fig. 6

The immunostaining analyses of Q84Pfs-Het and WT cortices at E16 with the NPC marker Pax6 (a, c) and the proliferation cell marker phosphorylated histone H3 (pHH3) (d, e). The quantification of cortex thickness (b), the thickness of Pax6+ progenitor areas (c), and the number of pHH3+ cells (e). Scale bars, 200 μm (lower magnification images in a, d), or 50 μm (higher magnification images in a, d). Thickness in (b, c) was measured in three independent areas per section (n = 3 mice/condition). The cell number in (e) was counted in three mice per condition. The error bars (b, c, e) represent SD. ****p < 0.0001 (b, c) and *p = 0.0412 (e) in unpaired two-tailed t tests. Only the representative images are shown.

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