Fig. 8: Q84Pfs-Het cortex exhibited axonal defects. | Nature Communications

Fig. 8: Q84Pfs-Het cortex exhibited axonal defects.

From: The patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome

Fig. 8

The immunostaining analyses of Q84Pfs-Het and WT brains with the axonal marker L1 and thalamocortical axonal marker NTNG1 at P0 (a), E16 (b, c), and P1 (d). Probst bundles (yellow arrow in a) were formed at the midline of Q84Pfs-Het brains, but not of WT brains. In addition, Q84Pfs-Het cortex exhibited an increase in displaced L1/NTNG1-double positive axonal bundles (yellow arrows in b), as quantified (c,d). Scale bars, 1 mm (a), or 200 μm (b). n = 4 mice/condition. The error bars represent SD. ***p = 0.0009 (c), ***p = 0.0003 (d) in unpaired two-tailed t test. Only representative images are shown.

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