Fig. 2: Clonal architecture of Wilms tumours.
From: High resolution clonal architecture of hypomutated Wilms tumours
a A schematic illustrates that with a conventional clonal architecture (left-hand phylogeny), a high proportion of the per-tumour-cell mutation burden may be captured by bulk sequencing. In contrast, with extensive polyclonal diversification (right-hand phylogeny) only a small proportion of the per-cell mutation burden is captured. The colour key applies to all the phylogenies shown below. b–f Phylogenies of Wilms tumours, newly generated using either single-cell-derived organoids laser capture microdissections. Every tip represents either a single-cell-derived organoid or a microbiopsy. g Previously published17 phylogeny of an adult colorectal cancer, constructed using whole genome sequencing of single-cell-derived organoids. h Previously published10 phylogeny of normal colonic crypts from an adult, constructed using whole genome sequencing of crypts isolated by laser capture microdissection. Source data are provided as a Source Data file.
