Fig. 3: Cluster 13 is associated with metastasis and chemotherapeutic resistance. | Nature Communications

Fig. 3: Cluster 13 is associated with metastasis and chemotherapeutic resistance.

From: Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression

Fig. 3

A Gene ontology analysis of Cluster 13 gene signature. B Representative CA125 immunohistochemistry in a primary HV bladder tumor and the corresponding lymph node metastasis (N = 4 of 5 cases examined). C Intratumoral comparison of Cluster 13 and parent tumor gene signature susceptibility to common bladder cancer chemotherapeutic agents in 5 HV tumors. D Kaplan–Meier curves of overall and disease-specific survival according to Cluster 13 signature enrichment in TCGA-BLCA (log-rank test, p = 0.01 for overall survival; p = 0.03 for disease-specific survival). Data are presented as mean values ± standard error. Source data are provided as a Source data file.

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