Fig. 8: SSNA-1 functions to stabilize centrioles during and after assembly. | Nature Communications

Fig. 8: SSNA-1 functions to stabilize centrioles during and after assembly.

From: C. elegans SSNA-1 is required for the structural integrity of centrioles and bipolar spindle assembly

Fig. 8

A model depicting the fate of centrioles possessing or lacking stabilizing elements. Top. Wild-type centrioles, which possess both SSNA-1 (yellow ring) and a fully formed cartwheel, exhibit long-term stability resulting in faithful bipolar spindle assembly. Middle. Centrioles lacking SSNA-1 can be assembled but lack long-term stability leading to centriole fragmentation and multipolar spindle formation. Bottom. Centrioles lacking SSNA-1 and a fully formed cartwheel (due to partial inhibition of zyg-1) experience structural failure during assembly leading to loss of the daughter centriole and monopolar spindle assembly. Microtubules are in purple, SSNA-1 is in yellow, and the cartwheel is in black. The green cylinder highlights the lumen of the centriole.

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