Fig. 1: Cell surface expression of 360 CB2R mutants.
From: Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R
A CB2R snake plot showing the distribution of mutants with low, WT-like, and high surface expression. These categories correspond to less than 80% (red), between 80% and 120% (gray), and more than 120% (yellow) of the wild-type expression level. B Barplot showing the distribution of the three expression categories: low, WT-like and high. C Relationship between evolutionary conservation of a residue and its impact on cell-surface expression upon mutation. The conservation score (Jensen-Shannon divergence) was computed for all residues within class A GPCRs. Residues with low conservation scores have the least effect on cell-surface expression, whereas high conservation scores can significantly impact cell-surface expression. Gray arrows indicate the increasing impact. WT surface expression level (100%) is shown with a solid horizontal gray line, while the two gray dashed lines delimit the boundaries of the WT-like expression level. Source data are provided as a Source Data file.
