Fig. 1: Single-cell transcriptome and spatial profiling of PitNETs. | Nature Communications

Fig. 1: Single-cell transcriptome and spatial profiling of PitNETs.

From: Single-cell and spatial transcriptome analyses reveal tumor heterogeneity and immune remodeling involved in pituitary neuroendocrine tumor progression

Fig. 1

a Overview of the study design depicted schematically. Created in BioRender. su, w. (2025) https://BioRender.com/7d5vpht. b H&E staining alongside visualization of single-cell spatial distribution of marker genes in PitNET. Scale bars, 1 mm. c UMAP plot illustrating the distinct cell clusters identified by scRNA-seq (n = 172,510 cells from 37 samples). d Bubble heatmap showing the marker genes for each cell cluster identified through scRNA-seq. e Stacked bar plot representing the proportions of major cell populations across different tumor subtypes. Source data are provided as a Source Data file for (d).

Back to article page