Fig. 2: Tumor-associated signatures of PitNETs at single-cell resolution. | Nature Communications

Fig. 2: Tumor-associated signatures of PitNETs at single-cell resolution.

From: Single-cell and spatial transcriptome analyses reveal tumor heterogeneity and immune remodeling involved in pituitary neuroendocrine tumor progression

Fig. 2

a UMAP plot showing the distribution of pituitary tumor and normal cell populations (n = 160,243 cells from 37 samples). b Heatmap of copy number variations (CNVs) in single pituitary cells from normal (top) and tumor (bottom) tissues, inferred from scRNA-seq data. c Heatmap depicting Pearson correlation among PitNET tumor clusters (n = 160,243 cells), with color intensity representing correlation strength. d Violin plot displaying gene expression profiles for regular ACTH adenomas (ACTH*,including ACTH1, ACTH2, ACTH3, ACTH4, ACTH7, ACTH8), SCA1 and regular SCAs (SCA*,including SCA2, SCA3, SCA4). Data are presented as mean values +/- SD. e Spatial gene expression patterns in ACTH2 (a regular ACTH adenoma), SCA1, and SCA5 (a regular SCA tumor). Source data are provided as a Source Data file for (c).

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