Fig. 10: Correlation analysis identifies divergent immune relationships between MARV and RAVV vaccines. | Nature Communications

Fig. 10: Correlation analysis identifies divergent immune relationships between MARV and RAVV vaccines.

From: Divergent antibody recognition profiles are generated by protective mRNA vaccines against Marburg and Ravn viruses

Fig. 10

A Unpaired, two-sided Welch’s t-test results for differential immune response parameters generated in the homologous challenge guinea pig cohort at day 54 post vaccination with MARV and RAVV mRNA (n = 5 per vaccine group). The outer limits of the box reflect the interquartile range (IQR: Q3–Q1) with median shown as horizontal bars. Whiskers extend to 1.5 times the IQR of the box. Outliers outside 1.5 × IQR are shown as individual points. B, C Heatmap two-tailed Pearson’s correlation matrix depicting pairwise associations between parameters measured at day 54 post vaccination for (B) each MARV or RAVV vaccine (n = 5 per vaccine group) or for (C) combined MARV and RAVV vaccines (n = 10). Pearson’s correlation coefficient values, where color intensity indicate higher correlation, and color represents direction of correlation: positive, blue; negative, red. P ≤ 0.05, **P ≤ 0.01 and ***P ≤ 0.001. Exact (B, C) correlation coefficient and (C) p-values are reported in the Source Data file.

Back to article page