Fig. 2: Screening the cysteinome reactivity of DPCCs at 5 μM concentration in vitro.
From: Proteome-wide ligandability maps of drugs with diverse cysteine-reactive chemotypes
a Schematic for QTRP experiments. b Radial bar chart summarizing the cysteine reactivity of each drug (RH/L ≥ 4). c. PCA plot comparing the target profiles of DPCCs and TCIs. d Kinome tree showing the kinases engaged by DPCCs and TCIs, respectively. e Pie chart showing the number of DPCC hits per engaged cysteines. f Pie chart showing the number of engaged cysteines per protein. g Bar chart comparing the number of liganded cysteines for each chemotype, with red and black indicating cysteines engaged by single or multiple chemotypes, respectively.
