Fig. 3: Profiling targets of DPCCs at 20 μM concentration in cells. | Nature Communications

Fig. 3: Profiling targets of DPCCs at 20 μM concentration in cells.

From: Proteome-wide ligandability maps of drugs with diverse cysteine-reactive chemotypes

Fig. 3

a Fraction of all quantified cysteines targeted by DPCCs in cellulo. b Fraction of all quantified proteins targeted by DPCCs in cellulo. c Heat map showing RH/L values of ‘hotspot’ cysteines that can be engaged by at least two DPCCs. NA: not detected. d Fraction of all quantified proteins recorded in DrugBank. e Functional categorization of DrugBank and non-DrugBank proteins with DPCC-engaged cysteines. f Stacked column chart showing the number of DPCC-engaged proteins within each functional annotation.

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