Fig. 3: Cross-validation and permutation analysis between DBS cohorts.

A Correlation maps for both the STN-DBS cohort (top left) and the VIM-DBS cohort (bottom right). These maps contain group-level correlation coefficients consisting of each patient’s hemisphere connectivity profile with their clinical tremor improvement. The connectivity of VIM-DBS patients to the STN connectivity profile correlated positively with clinical improvement (top) in a two-sided Spearman correlation, and vice versa for STN patients with VIM profiles (bottom). No adjustment for multiple comparisons was applied. The shaded area indicates the 95% confidence interval. Cerebellar flatmaps were created using the SUIT toolbox⁶². B Results of a permutation analysis for VIM connectivity maps predicting STN-DBS outcomes (left), STN connectivity maps predicting VIM-DBS outcomes (right), and both combined (middle). DBS Deep Brain Stimulation, FTM Fahn-Tolosa-Marin Tremor Rating Scale, STN Subthalamic nucleus, UPDRS-III Unified Parkinson’s Disease Rating Scale, part III, VIM Ventral intermediate nucleus of the thalamus.