Fig. 5: In vivo PK and PD studies of Pro-BA.
From: Linker-free PROTACs efficiently induce the degradation of oncoproteins
A Pro-BA was administered to mice at a dose of 2 mg/kg in ddH2O via I.V. injection and 10 mg/kg in ddH2O via P.O. route, respectively. Plasma drug concentrations were assessed utilizing HPLC. Data are presented as the mean ± SD (n = 3 mice per group). B PK parameters of Pro-BA following a single dose via I.V. injection (2 mg/kg) and P.O. route (10 mg/kg). C H3122 tumor-bearing nude mice received either vehicle (ddH2O) or Pro-BA (10 mg/kg in ddH2O) via P.O. route. Tumor tissues were collected and analyzed by immunoblotting to detect indicated proteins after 48 h of treatment (upper panel). The corresponding quantification of protein levels from the western blot data is provided (lower panel). Data are presented as the mean ± SD (n = 3 mice per group), two-tailed Student’s t-test. Source data are provided as a Source Data file.
