Fig. 1: Metastatic characteristics of SCLC.
From: FOXA2 promotes metastatic competence in small cell lung cancer
a Metastatic characteristics of an MSK-SCLC cohort (N = 327). Localized disease (left) including the fraction of never-metastasized cases (dark blue). Frequency (middle) and number (right) of distant metastatic sites are shown among cases with any metastases. LN: Lymph node. b Schematic of the approach to metastatic subline generation in SCLC cell lines. i.c.: intra-cardiac injection. Created in BioRender. Rudin C. (2025) https://BioRender.com/j5rkxx5. c Frequency and distribution of metastases in H1836 (ASCL1 subtype) and H82 (NEUROD1 subtype) SCLC cell lines, and Lx773I SCLC PDX (POU2F3 subtype) parental lines and organ-specific sublines after intracardiac implantation.
