Table 1 Pearson correlation coefficient and P value (in parenthesis) for a multivariable regression model trained to predict the change in VAS scores (“outcome”) using the top k features most correlated with the outcome

From: On-chip 3D potency assay for prediction of clinical outcomes for cell therapy candidates for osteoarthritis

k

On-chip 3D simSF

On-chip 3D ctrl

2D simSF

1

0.52 (0.0237) PD-L1

0.46 (0.0482) IL-17

0.20 (ns, 0.416) TNF R1

2

0.52 (0.0224) PD-L1, HGF

0.49 (0.0330) IL-17, VCAM-1

0.40 (ns, 0.0942) MMP-3, VEGF

3

0.56 (0.0130) TNF-α, IL-6, VCAM-1

0.53 (0.0197) HGF, IL-17, TNF R1

0.44 (ns, 0.0588) IL-6, MMP-3, VEGF

  1. Results are shown for each of the assay platforms in separate columns and analytes corresponding to k features are listed below the Pearson correlation coefficient. A two-sided t-test was used.
  2. ns not significant.
  3. Statistically significant Pearson correlation coefficients are shown in bold.
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