Fig. 1: Haematopoietic and non-haematopoietic CXCR2 is required for host defense during bacterial pneumonia. | Nature Communications

Fig. 1: Haematopoietic and non-haematopoietic CXCR2 is required for host defense during bacterial pneumonia.

From: Alveolar epithelial and vascular CXCR2 mediates transcytosis of CXCL1 in inflamed lungs

Fig. 1

CXCR2 KO mice (red = CXCR2−/−, green = CXCR2fl/flCdh5Cre+, blue = CXCR2fl/flShhCre+) and appropriate WT/Cre- control (gray) mice were intratracheally administered with sterile saline or with viable K. pneumoniae. Neutrophil recruitment into the lung (A, D, G), as well as CFUs in the lung (B, E, H) and spleen (C, F, I) were assessed 24 h after infection. Data are mean ± SD, n = 5–10 biologically independent mice pre group, age 8–16 weeks, equal gender distribution, one-way ANOVA followed by Bonferroni correction, *p < 0.05, **p < 0.01.

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