Fig. 2: Endothelial and epithelial CXCR2 are required for host defense during K. pneumoniae-induced pneumonia. | Nature Communications

Fig. 2: Endothelial and epithelial CXCR2 are required for host defense during K. pneumoniae-induced pneumonia.

From: Alveolar epithelial and vascular CXCR2 mediates transcytosis of CXCL1 in inflamed lungs

Fig. 2

CXCR2 KO mice (red=CXCR2−/−, green=CXCR2fl/flCdh5Cre+, blue=CXCR2fl/flShhCre+) and appropriate WT/Cre- control (gray) mice were intratracheally administered with sterile saline or with viable K. pneumoniae. Neutrophil recruitment into BAL (A, D, G), as well as CFUs in the BAL (B, E, H) and blood (C, F, I) were assessed 24 h after infection. Data are mean ± SD, n = 5–10 biologically independent mice pre group, age 8–16 weeks, equal gender distribution, one-way ANOVA followed by Bonferroni correction, *p < 0.05, **p < 0.01.

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