Fig. 5: Neutrophil recruitment in cremaster and kidney tissue is not altered in CXCR2fl/flCdh5Cre+ mice.
From: Alveolar epithelial and vascular CXCR2 mediates transcytosis of CXCL1 in inflamed lungs
CXCR2fl/flCdh5Cre+ and Cre− mice were analyzed for neutrophil recruitment after acute inflammation of the cremaster muscle (A–F). Adherent and emigrated cells were analyzed after TNF stimulation (A, B) and CXCL1 superfusion of the cremaster muscle (C, D) or before and after fMLP superfusion (E, F). Neutrophil recruitment into the kidney (G) and plasma creatinine (H) were evaluated in CXCR2fl/flCdh5Cre+ and Cre− control mice after ischemia reperfusion injury (IRI). Data are mean ± SD, n = 3–4 biologically independent mice pre group, age 8–16 weeks, only male mice for cremaster IMV, all other equal gender distribution, t-test.
