Fig. 1: Intraoperative setup and data analysis. | Nature Communications

Fig. 1: Intraoperative setup and data analysis.

From: Refining centromedian nucleus stimulation for generalized epilepsy with targeting and mechanistic insights from intraoperative electrophysiology

Fig. 1

a Experimental setup of the ROSA robot advancing three microelectrodes through the CM centromedian nucleus and vicinity, LV lateral ventricle, III third ventricle, HB habenula nucleus, MD mediodorsal nucleus, Vc ventral caudal nucleus, VIM ventralis intermediate nucleus, PF parafascicular nucleus, IML internal medullary lamina. b Top: Example processed trace of the multi-unit data recorded from the microelectrode with the subsequent peak detection. Bottom: An example of the firing rates across all the implant depths is shown cLeft: Map of sub-scalp 10–20 system electroencephalogram (EEG) electrode locations. Center: Example sub-scalp EEG trace during stimulation trials. Right: Example sub-scalp EEG signal spectrogram during the stimulation phase. Source data for (b, c) are provided as a Source Data file.

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