Fig. 2: Plasma and vegetation proteomic modules associated with clinical traits of IE.

A–D Module–trait associations and characterization in the plasma and vegetation proteomes. Heatmap (A, C) showing the correlation between modules and clinical traits. Each row corresponds to a module. Each column corresponds to a clinical trait. The color range represents correlation coefficients. Bubble chart (B, D) outlining the pathways significantly enriched for the proteins in different modules. The bubble size corresponds to the significance of the pathways enriched in each module, and the colors correspond to the modules. E-J Hub proteins associated with ICU stays in the plasma (E–G) and vegetation (H-J) proteomic modules. Scatter plots (E, H) displaying the hub proteins associated with the ICU stays in the plasma and vegetation proteomes, respectively. The x-axis represents the correlation between proteins and their corresponding modules, and the y-axis represents the correlation between proteins and the ICU stays. The color range represents the significance of the correlation between hub proteins and the ICU stays, indicated by -log10p-value. Bar charts (F, I) showing pathways significantly enriched for the hub proteins. STRING analysis (G, J) showing the protein-protein interactions (PPIs) of the hub proteins. For figures (A, C, E, H), two-sided Pearson’s correlation (WGCNA-derived) was used, with significance denoted by *p < 0.05, **p < 0.01, ***p < 0.001. Abbreviations: CPB, cardiopulmonary bypass time; previous CE, previous cerebral embolism; CABG, coronary artery bypass grafting. Source data are provided as Source Data files.