Fig. 7: Plasma proteomic alterations following cardiac surgery in IE. | Nature Communications

Fig. 7: Plasma proteomic alterations following cardiac surgery in IE.

From: Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment

Fig. 7

A Heatmap showing two plasma protein panels with gradually decreasing (top) or increasing abundance (bottom) from preoperative IE to postoperative IE and non-IE group, along with pathway enrichment (right). B Venn diagram illustrating 7 plasma proteins associated with the high-yield score and decreased in the postoperative IE samples. C Venn diagram illustrating 18 plasma proteins associated with the low-yield score and increased in the postoperative IE samples. D Scatter plot showing the correlation between the relative levels (log2) of NDUFB4 (x-axis) and inflammatory indicators (y-axis). E Scatter plot displaying the correlations of NDUFB4 with other proteins in the plasma proteome. F Bubble chart showing enriched pathways in the proteins correlated with NDUFB4 (R > 0.2; p < 0.05). G Schematic of the potential role of NDUFB4 in facilitating resistance to infection in IE. H Graphical summary of key molecular findings, highlighting potential biomarkers and treatment targets for IE, spanning early diagnosis to pathophysiology and treatment. For figures (D–F), the two-sided Spearman’s correlation was used, with p-values adjusted for FDR. Source data are provided as Source Data files.

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