Fig. 7: Model: coordinated action of multiple histone modifications during ZGA in teleost embryos. | Nature Communications

Fig. 7: Model: coordinated action of multiple histone modifications during ZGA in teleost embryos.

From: Coordinated action of multiple active histone modifications shapes the zygotic genome activation in teleost embryos

Fig. 7

During ZGA in teleost embryos, only developmental genes are activated by CBP/P300. CBP/P300 regulates Pol II initiation and deposits histone acetylations such as H3K27ac. BRD4 binds to H3K27ac and induces pause-release and elongation of Pol II. CBP/P300 activity also accumulates H3K4me2, but H3K4me2 is dispensable for ZGA. The activity of CBP/P300 is enhanced specifically during ZGA by temporal accumulation of H3.3S31ph. In contrast, activation of housekeeping genes is CBP/P300-independent. Alternatively, GCN5, MOF and HBO1 activity, or their substrates H3K9ac, H4K16ac and H3K14ac, are suggested to be involved in the activation of housekeeping genes. H3K4me2/3 accumulates at active gene promoters but is not prerequisite for their gene expression.

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