Fig. 5: IsoNet fulfils the glutathione metabolic reaction network. | Nature Communications

Fig. 5: IsoNet fulfils the glutathione metabolic reaction network.

From: Charting unknown metabolic reactions by mass spectrometry-resolved stable-isotope tracing metabolomics

Fig. 5

a An integrated glutathione metabolic network combined with datasets of positive and negative ionization modes. b The glutathione metabolic reaction network including 10 metabolic reactions. c PCA analysis of individual metabolite treatments. Metabolite intensities were normalized to their respective control group. d Significantly enriched pathways of individual metabolite treatment experiments. Pathway enrichment p-values were calculated using the hypergeometric test (unadjusted). The circle size represents the number of metabolite hits in the pathway. The color represents raw p-value of enrichment. Source data are provided as Source Data files for Fig. 5c, d.

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