Fig. 4: PathAnalyzeR describes metabolic differences in BAT LAMs of db/db and HFD mice. | Nature Communications

Fig. 4: PathAnalyzeR describes metabolic differences in BAT LAMs of db/db and HFD mice.

From: MACanalyzeR scRNAseq analysis tool reveals PPARγHIGH/GDF15HIGH lipid-associated macrophages facilitate thermogenic expansion in BAT

Fig. 4

A, B Heatmaps of PathAnalyzeR analysis using KEGG metabolic pathways related to roles or components unique to macrophages. Plotted by condition (A) and by macrophage subcluster (B). C Heatmap representation of gene expression of Lipid Metabolism, OXPHOS and Lysosome pathways. Plotted by condition (upper panel) and by macrophage subclusters (lower panel). D, E PathAnalyzeR 2D density plots splitted by condition using OXPHOS and Fatty Acid metabolism KEGG pathways (D) Lysosome and Mitochondria GO terms. F 2D density plots of GO Fatty Acid Biosynthetic and Catabolic processes splitted by condition. G KEGG Fatty Acid Biosynthetic Process and Oxidative Phosphorylation 2D plots splitted both by condition and cell type.

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