Fig. 3: Comparison of the dependence of linear vs isotropic ADC-fMRI on white matter fibre angle.
From: Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI
The diffusion encoding direction from the linear dfMRI sequence was used as a reference to measure the angle to the largest FOD peak in each active voxel in subject-level spatial maps (general linear model, cluster-corrected, z ≥ 2.3, p < 0.05), shown as a density distribution of significant voxels as a function of angle (A) and as the percentage change in ADC during visual stimulation for each voxel, as a function of angle (B). Simulated ADC changes when in silico axons swell to 0–1% of their original volume are plotted as a function of angle for linear ADC-fMRI (C) and isotropic ADC-fMRI (D). ADC Apparent Diffusion Coefficient.
